An active DNA-based nanoprobe for photoacoustic pH imaging.
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ABSTRACT:
SUBMITTER: Baumann KN
PROVIDER: S-EPMC6127833 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Publications
An active DNA-based nanoprobe for photoacoustic pH imaging.
Baumann Kevin N KN Fux Alexandra C AC Joseph James J Bohndiek Sarah E SE Hernández-Ainsa Silvia S
Chemical communications (Cambridge, England) 20180901 72
We report an active DNA construct capable of probing pH through a photoacoustic (PA) ratiometric analysis approach. Our nanoprobe enables different PA readout in tissue mimicking phantoms in the range between pH 6.8 to 7.8 at physiologically relevant sodium concentrations. Thus, it represents a promising platform to probe pH values relevant to the tumor microenvironment using PA. ...[more]
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