Ontology highlight
ABSTRACT:
SUBMITTER: Amort T
PROVIDER: S-EPMC4111728 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Amort Thomas T Soulière Marie F MF Wille Alexandra A Jia Xi-Yu XY Fiegl Heidi H Wörle Hildegard H Micura Ronald R Lusser Alexandra A
RNA biology 20130401 6
Post-synthetic modifications of nucleic acids have long been known to affect their functional and structural properties. For instance, numerous different chemical modifications modulate the structural organization, stability or translation efficiency of tRNAs and rRNAs. In contrast, little is known about modifications of poly(A)RNAs. Here, we demonstrate for the first time that the two well-studied regulatory long non-coding RNAs HOTAIR and XIST are targets of site-specific cytosine methylation. ...[more]