Ontology highlight
ABSTRACT:
SUBMITTER: Pietrocola F
PROVIDER: S-EPMC4111762 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Pietrocola Federico F Malik Shoaib Ahmad SA Mariño Guillermo G Vacchelli Erika E Senovilla Laura L Chaba Kariman K Niso-Santano Mireia M Maiuri Maria Chiara MC Madeo Frank F Kroemer Guido G
Cell cycle (Georgetown, Tex.) 20140425 12
Epidemiological studies and clinical trials revealed that chronic consumption coffee is associated with the inhibition of several metabolic diseases as well as reduction in overall and cause-specific mortality. We show that both natural and decaffeinated brands of coffee similarly rapidly trigger autophagy in mice. One to 4 h after coffee consumption, we observed an increase in autophagic flux in all investigated organs (liver, muscle, heart) in vivo, as indicated by the increased lipidation of ...[more]