Ontology highlight
ABSTRACT:
SUBMITTER: Congdon EE
PROVIDER: S-EPMC3405840 | biostudies-other | 2012 Apr
REPOSITORIES: biostudies-other
Congdon Erin E EE Wu Jessica W JW Myeku Natura N Figueroa Yvette H YH Herman Mathieu M Marinec Paul S PS Gestwicki Jason E JE Dickey Chad A CA Yu W Haung WH Duff Karen E KE
Autophagy 20120401 4
More than 30 neurodegenerative diseases including Alzheimer disease (AD), frontotemporal lobe dementia (FTD), and some forms of Parkinson disease (PD) are characterized by the accumulation of an aggregated form of the microtubule-binding protein tau in neurites and as intracellular lesions called neurofibrillary tangles. Diseases with abnormal tau as part of the pathology are collectively known as the tauopathies. Methylthioninium chloride, also known as methylene blue (MB), has been shown to re ...[more]