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Lycopodine-Type Alkaloids from Lycopodium japonicum.

ABSTRACT: Three new lycopodine-type alkaloids, 4α-hydroxyanhydrolycodoline (1), 4α,6α-dihydroxyanhydrolycodoline (2), and 6-epi-8β-acetoxylycoclavine (3), and an artifact, lycoposerramine G nitrate (4), along with seventeen related known compounds, were isolated from the club moss Lycopodium japonicum Thunb. ex Murray (Lycopodiaceae). Their structures were elucidated by extensive spectroscopic methods as well as X-ray analysis. Compounds 1-4 were evaluated for their acetylcholine esterase inhibitory activity.

SUBMITTER: He J

PROVIDER: S-EPMC4111880 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature

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Lycopodine-Type Alkaloids from Lycopodium japonicum.

He Juan J Wu Xing-De XD Liu Fei F Liu Yu-Cheng YC Peng Li-Yan LY Zhao Yu Y Cheng Xiao X Luo Huai-Rong HR Zhao Qin-Shi QS

Natural products and bioprospecting 20140717 4

Three new lycopodine-type alkaloids, 4α-hydroxyanhydrolycodoline (1), 4α,6α-dihydroxyanhydrolycodoline (2), and 6-epi-8β-acetoxylycoclavine (3), and an artifact, lycoposerramine G nitrate (4), along with seventeen related known compounds, were isolated from the club moss Lycopodium japonicum Thunb. ex Murray (Lycopodiaceae). Their structures were elucidated by extensive spectroscopic methods as well as X-ray analysis. Compounds 1-4 were evaluated for their acetylcholine esterase inhibitory activ ...[more]

PMID: 25089239

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