Direct methoxypyridine functionalization approach to magellanine-type Lycopodium alkaloids.

ABSTRACT: A concise enantioselective approach to the tetracyclic core of the magellanine-type Lycopodium alkaloids is reported. Key to this approach is the use of the Hajos-Parrish reaction to set a challenging quaternary stereocenter, thereby guiding the stereoselectivity for the remainder of the synthesis, as well as the use of a palladium-mediated direct pyridine functionalization reaction to forge the tetracyclic core.

SUBMITTER: Murphy RA 

PROVIDER: S-EPMC3262889 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature