Ontology highlight
ABSTRACT:
SUBMITTER: Eswarappa SM
PROVIDER: S-EPMC4113015 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Eswarappa Sandeepa M SM Potdar Alka A AA Koch William J WJ Fan Yi Y Vasu Kommireddy K Lindner Daniel D Willard Belinda B Graham Linda M LM DiCorleto Paul E PE Fox Paul L PL
Cell 20140601 7
Translational readthrough, observed primarily in less complex organisms from viruses to Drosophila, expands the proteome by translating select transcripts beyond the canonical stop codon. Here, we show that vascular endothelial growth factor A (VEGFA) mRNA in mammalian endothelial cells undergoes programmed translational readthrough (PTR) generating VEGF-Ax, an isoform containing a unique 22-amino-acid C terminus extension. A cis-acting element in the VEGFA 3' UTR serves a dual function, not onl ...[more]