Ontology highlight
ABSTRACT:
SUBMITTER: Kathman SG
PROVIDER: S-EPMC4113264 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Kathman Stefan G SG Xu Ziyang Z Statsyuk Alexander V AV
Journal of medicinal chemistry 20140528 11
A novel fragment-based drug discovery approach is reported which irreversibly tethers drug-like fragments to catalytic cysteines. We attached an electrophile to 100 fragments without significant alterations in the reactivity of the electrophile. A mass spectrometry assay discovered three nonpeptidic inhibitors of the cysteine protease papain. The identified compounds display the characteristics of irreversible inhibitors. The irreversible tethering system also displays specificity: the three ide ...[more]