Ontology highlight
ABSTRACT:
SUBMITTER: Gautier EL
PROVIDER: S-EPMC4113942 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Gautier Emmanuel L EL Ivanov Stoyan S Williams Jesse W JW Huang Stanley Ching-Cheng SC Marcelin Genevieve G Fairfax Keke K Wang Peter L PL Francis Jeremy S JS Leone Paola P Wilson David B DB Artyomov Maxim N MN Pearce Edward J EJ Randolph Gwendalyn J GJ
The Journal of experimental medicine 20140714 8
The transcription factor Gata6 regulates proliferation and differentiation of epithelial and endocrine cells and cancers. Among hematopoietic cells, Gata6 is expressed selectively in resident peritoneal macrophages. We thus examined whether the loss of Gata6 in the macrophage compartment affected peritoneal macrophages, using Lyz2-Cre x Gata6(flox/flox) mice to tackle this issue. In Lyz2-Cre x Gata6(flox/flox) mice, the resident peritoneal macrophage compartment, but not macrophages in other org ...[more]