Ontology highlight
ABSTRACT:
SUBMITTER: Rajsbaum R
PROVIDER: S-EPMC4114019 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Rajsbaum Ricardo R Versteeg Gijs A GA Schmid Sonja S Maestre Ana M AM Belicha-Villanueva Alan A Martínez-Romero Carles C Patel Jenish R JR Morrison Juliet J Pisanelli Giuseppe G Miorin Lisa L Laurent-Rolle Maudry M Moulton Hong M HM Stein David A DA Fernandez-Sesma Ana A tenOever Benjamin R BR García-Sastre Adolfo A
Immunity 20140529 6
Type I interferons (IFN-I) are essential antiviral cytokines produced upon microbial infection. IFN-I elicits this activity through the upregulation of hundreds of IFN-I-stimulated genes (ISGs). The full breadth of ISG induction demands activation of a number of cellular factors including the IκB kinase epsilon (IKKε). However, the mechanism of IKKε activation upon IFN receptor signaling has remained elusive. Here we show that TRIM6, a member of the E3-ubiquitin ligase tripartite motif (TRIM) fa ...[more]