Ontology highlight
ABSTRACT:
SUBMITTER: Okamoto S
PROVIDER: S-EPMC4114155 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Okamoto Shu-Ichi S Nakamura Tomohiro T Cieplak Piotr P Chan Shing Fai SF Kalashnikova Evgenia E Liao Lujian L Saleem Sofiyan S Han Xuemei X Clemente Arjay A Nutter Anthony A Sances Sam S Brechtel Christopher C Haus Daniel D Haun Florian F Sanz-Blasco Sara S Huang Xiayu X Li Hao H Zaremba Jeffrey D JD Cui Jiankun J Gu Zezong Z Nikzad Rana R Harrop Anne A McKercher Scott R SR Godzik Adam A Yates John R JR Lipton Stuart A SA
Cell reports 20140704 1
Redox-mediated posttranslational modifications represent a molecular switch that controls major mechanisms of cell function. Nitric oxide (NO) can mediate redox reactions via S-nitrosylation, representing transfer of an NO group to a critical protein thiol. NO is known to modulate neurogenesis and neuronal survival in various brain regions in disparate neurodegenerative conditions. However, a unifying molecular mechanism linking these phenomena remains unknown. Here, we report that S-nitrosylati ...[more]