Ontology highlight
ABSTRACT:
SUBMITTER: Schneider A
PROVIDER: S-EPMC1172228 | biostudies-literature | 2005 Aug
REPOSITORIES: biostudies-literature
Schneider Armin A Krüger Carola C Steigleder Tobias T Weber Daniela D Pitzer Claudia C Laage Rico R Aronowski Jaroslaw J Maurer Martin H MH Gassler Nikolaus N Mier Walter W Hasselblatt Martin M Kollmar Rainer R Schwab Stefan S Sommer Clemens C Bach Alfred A Kuhn Hans-Georg HG Schäbitz Wolf-Rüdiger WR
The Journal of clinical investigation 20050707 8
G-CSF is a potent hematopoietic factor that enhances survival and drives differentiation of myeloid lineage cells, resulting in the generation of neutrophilic granulocytes. Here, we show that G-CSF passes the intact blood-brain barrier and reduces infarct volume in 2 different rat models of acute stroke. G-CSF displays strong anti-apoptotic activity in mature neurons and activates multiple cell survival pathways. Both G-CSF and its receptor are widely expressed by neurons in the CNS, and their e ...[more]