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Simultaneous transcranial magnetic stimulation and single-neuron recording in alert non-human primates.


ABSTRACT: Transcranial magnetic stimulation (TMS) is a widely used, noninvasive method for stimulating nervous tissue, yet its mechanisms of effect are poorly understood. Here we report new methods for studying the influence of TMS on single neurons in the brain of alert non-human primates. We designed a TMS coil that focuses its effect near the tip of a recording electrode and recording electronics that enable direct acquisition of neuronal signals at the site of peak stimulus strength minimally perturbed by stimulation artifact in awake monkeys (Macaca mulatta). We recorded action potentials within ?1 ms after 0.4-ms TMS pulses and observed changes in activity that differed significantly for active stimulation as compared with sham stimulation. This methodology is compatible with standard equipment in primate laboratories, allowing easy implementation. Application of these tools will facilitate the refinement of next generation TMS devices, experiments and treatment protocols.

SUBMITTER: Mueller JK 

PROVIDER: S-EPMC4115015 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature

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Simultaneous transcranial magnetic stimulation and single-neuron recording in alert non-human primates.

Mueller Jerel K JK   Grigsby Erinn M EM   Prevosto Vincent V   Petraglia Frank W FW   Rao Hrishikesh H   Deng Zhi-De ZD   Peterchev Angel V AV   Sommer Marc A MA   Egner Tobias T   Platt Michael L ML   Grill Warren M WM  

Nature neuroscience 20140629 8


Transcranial magnetic stimulation (TMS) is a widely used, noninvasive method for stimulating nervous tissue, yet its mechanisms of effect are poorly understood. Here we report new methods for studying the influence of TMS on single neurons in the brain of alert non-human primates. We designed a TMS coil that focuses its effect near the tip of a recording electrode and recording electronics that enable direct acquisition of neuronal signals at the site of peak stimulus strength minimally perturbe  ...[more]

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