Ontology highlight
ABSTRACT:
SUBMITTER: Evfratov SA
PROVIDER: S-EPMC4115225 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Evfratov S A SA Smekalova E M EM Golovin A V AV Logvina N A NA Zvereva M I MI Dontsova O A OA
Acta naturae 20140401 2
Telomere length, an important feature of life span control, is dependent on the activity of telomerase (a key enzyme of the telomere-length-maintaining system). Telomerase RNA is a component of telomerase and, thus, is crucial for its activity. The structures of telomerase RNA genes and their promoter regions were compared for the long-living naked mole rat and different organisms. Two rare polymorphisms in Heterocephalus glaber telomerase RNA (hgTER) were identified: A→G in the first loop of ps ...[more]