Unknown

Dataset Information

0

Characterization of brown adipose tissue thermogenesis in the naked mole-rat (Heterocephalus glaber), a heterothermic mammal.


ABSTRACT: The naked mole-rat (NMR) is a heterothermic mammal that forms eusocial colonies consisting of one reproductive female (queen), several reproductive males, and subordinates. Despite their heterothermy, NMRs possess brown adipose tissue (BAT), which generally induces thermogenesis in cold and some non-cold environments. Previous studies suggest that NMR-BAT induces thermogenesis by cold exposure. However, detailed NMR-BAT characteristics and whether NMR-BAT thermogenesis occurs in non-cold environments are unknown. Here, we show beta-3 adrenergic receptor (ADRB3)-dependent thermogenic potential of NMR-BAT, which contributes to thermogenesis in the isolated queen in non-cold environments (30 °C). NMR-BAT expressed several brown adipocyte marker genes and showed noradrenaline-dependent thermogenic activity in vitro and in vivo. Although our ADRB3 inhibition experiments revealed that NMR-BAT thermogenesis slightly delays the decrease in body temperature in a cold environment (20 °C), it was insufficient to prevent the decrease in the body temperatures. Even at 30 °C, NMRs are known to prevent the decrease of and maintain their body temperature by heat-sharing behaviors within the colony. However, isolated NMRs maintained their body temperature at the same level as when they are in the colony. Interestingly, we found that queens, but not subordinates, induce BAT thermogenesis in this condition. Our research provides novel insights into NMR thermoregulation.

SUBMITTER: Oiwa Y 

PROVIDER: S-EPMC7656259 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature

altmetric image

Publications

Characterization of brown adipose tissue thermogenesis in the naked mole-rat (Heterocephalus glaber), a heterothermic mammal.

Oiwa Yuki Y   Oka Kaori K   Yasui Hironobu H   Higashikawa Kei K   Bono Hidemasa H   Kawamura Yoshimi Y   Miyawaki Shingo S   Watarai Akiyuki A   Kikusui Takefumi T   Shimizu Atsushi A   Okano Hideyuki H   Kuge Yuji Y   Kimura Kazuhiro K   Okamatsu-Ogura Yuko Y   Miura Kyoko K  

Scientific reports 20201110 1


The naked mole-rat (NMR) is a heterothermic mammal that forms eusocial colonies consisting of one reproductive female (queen), several reproductive males, and subordinates. Despite their heterothermy, NMRs possess brown adipose tissue (BAT), which generally induces thermogenesis in cold and some non-cold environments. Previous studies suggest that NMR-BAT induces thermogenesis by cold exposure. However, detailed NMR-BAT characteristics and whether NMR-BAT thermogenesis occurs in non-cold environ  ...[more]

Similar Datasets

| S-EPMC3743245 | biostudies-literature
2011-10-12 | GSE30337 | GEO
| S-EPMC2214810 | biostudies-literature
| S-EPMC4115225 | biostudies-literature
| S-EPMC5142786 | biostudies-literature
2011-10-12 | E-GEOD-30337 | biostudies-arrayexpress
| S-EPMC4081180 | biostudies-literature
| S-EPMC9250917 | biostudies-literature
| S-EPMC7487461 | biostudies-literature
| S-EPMC5769652 | biostudies-literature