Ontology highlight
ABSTRACT:
SUBMITTER: Tomei AA
PROVIDER: S-EPMC4115512 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Tomei Alice A AA Manzoli Vita V Fraker Christopher A CA Giraldo Jaime J Velluto Diana D Najjar Mejdi M Pileggi Antonello A Molano R Damaris RD Ricordi Camillo C Stabler Cherie L CL Hubbell Jeffrey A JA
Proceedings of the National Academy of Sciences of the United States of America 20140630 29
Encapsulation of islets of Langerhans may represent a way to transplant islets in the absence of immunosuppression. Traditional methods for encapsulation lead to diffusional limitations imposed by the size of the capsules (600-1,000 μm in diameter), which results in core hypoxia and delayed insulin secretion in response to glucose. Moreover, the large volume of encapsulated cells does not allow implantation in sites that might be more favorable to islet cell engraftment. To address these issues, ...[more]