Ontology highlight
ABSTRACT:
SUBMITTER: Helander S
PROVIDER: S-EPMC4116274 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Helander Sara S Montecchio Meri M Lemak Alexander A Farès Christophe C Almlöf Jonas J Yi Yanjun Y Yee Adelinda A Arrowsmith Cheryl C DhePaganon Sirano S Sunnerhagen Maria M
Biochemical and biophysical research communications 20140322 1
In this paper, we describe the structure of a N-terminal domain motif in nuclear-localized FKBP251-73, a member of the FKBP family, together with the structure of a sequence-related subdomain of the E3 ubiquitin ligase HectD1 that we show belongs to the same fold. This motif adopts a compact 5-helix bundle which we name the Basic Tilted Helix Bundle (BTHB) domain. A positively charged surface patch, structurally centered around the tilted helix H4, is present in both FKBP25 and HectD1 and is con ...[more]