Ontology highlight
ABSTRACT:
SUBMITTER: Dersh D
PROVIDER: S-EPMC4116297 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Dersh Devin D Jones Stephanie M SM Eletto Davide D Christianson John C JC Argon Yair Y
Molecular biology of the cell 20140604 15
The tight coupling of protein folding pathways with disposal mechanisms promotes the efficacy of protein production in the endoplasmic reticulum (ER). It has been hypothesized that the ER-resident molecular chaperone glucose-regulated protein 94 (GRP94) is part of this quality control coupling because it supports folding of select client proteins yet also robustly associates with the lectin osteosarcoma amplified 9 (OS-9), a component involved in ER-associated degradation (ERAD). To explore this ...[more]