Ontology highlight
ABSTRACT:
SUBMITTER: Lin WY
PROVIDER: S-EPMC4116485 | biostudies-literature | 2013 Sep
REPOSITORIES: biostudies-literature
Lin Wan-Yu WY Yi Nengjun N Lou Xiang-Yang XY Zhi Degui D Zhang Kui K Gao Guimin G Tiwari Hemant K HK Liu Nianjun N
Genetic epidemiology 20130605 6
For most complex diseases, the fraction of heritability that can be explained by the variants discovered from genome-wide association studies is minor. Although the so-called "rare variants" (minor allele frequency [MAF] < 1%) have attracted increasing attention, they are unlikely to account for much of the "missing heritability" because very few people may carry these rare variants. The genetic variants that are likely to fill in the "missing heritability" include uncommon causal variants (MAF ...[more]