White matter changes with age utilizing quantitative diffusion MRI.
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ABSTRACT: Objective
To investigate the relationship between older age and mean cerebral white matter fiber bundle lengths (FBLs) in specific white matter tracts in the brain using quantified diffusion MRI.Methods
Sixty-three healthy adults older than 50 years underwent diffusion tensor imaging. Tractography tracings of cerebral white matter fiber bundles were derived from the diffusion tensor imaging data.Results
Results revealed significantly shorter FBLs in the anterior thalamic radiation for every 1-year increase over the age of 50 years.Conclusions
We investigated the effects of age on FBL in specific white matter tracts in the brains of healthy older individuals utilizing quantified diffusion MRI. The results revealed a significant inverse relationship between age and FBL. Longitudinal studies of FBL across a lifespan are needed to examine the specific changes to the integrity of white matter.
SUBMITTER: Baker LM
PROVIDER: S-EPMC4117364 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Publications
White matter changes with age utilizing quantitative diffusion MRI.
Baker Laurie M LM Laidlaw David H DH Conturo Thomas E TE Hogan Joseph J Zhao Yi Y Luo Xi X Correia Stephen S Cabeen Ryan R Lane Elizabeth M EM Heaps Jodi M JM Bolzenius Jacob J Salminen Lauren E LE Akbudak Erbil E McMichael Amanda R AR Usher Christina C Behrman Ashley A Paul Robert H RH
Neurology 20140613 3
<h4>Objective</h4>To investigate the relationship between older age and mean cerebral white matter fiber bundle lengths (FBLs) in specific white matter tracts in the brain using quantified diffusion MRI.<h4>Methods</h4>Sixty-three healthy adults older than 50 years underwent diffusion tensor imaging. Tractography tracings of cerebral white matter fiber bundles were derived from the diffusion tensor imaging data.<h4>Results</h4>Results revealed significantly shorter FBLs in the anterior thalamic ...[more]
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