Ontology highlight
ABSTRACT:
SUBMITTER: Loving KA
PROVIDER: S-EPMC4117425 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Loving Kathryn A KA Lin Andy A Cheng Alan C AC
PLoS computational biology 20140731 7
Advances reported over the last few years and the increasing availability of protein crystal structure data have greatly improved structure-based druggability approaches. However, in practice, nearly all druggability estimation methods are applied to protein crystal structures as rigid proteins, with protein flexibility often not directly addressed. The inclusion of protein flexibility is important in correctly identifying the druggability of pockets that would be missed by methods based solely ...[more]