Novel approach identifies SNPs in SLC2A10 and KCNK9 with evidence for parent-of-origin effect on body mass index.
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ABSTRACT:
SUBMITTER: Hoggart CJ
PROVIDER: S-EPMC4117451 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
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Novel approach identifies SNPs in SLC2A10 and KCNK9 with evidence for parent-of-origin effect on body mass index.
Hoggart Clive J CJ Venturini Giulia G Mangino Massimo M Gomez Felicia F Ascari Giulia G Zhao Jing Hua JH Teumer Alexander A Winkler Thomas W TW Tšernikova Natalia N Luan Jian'an J Mihailov Evelin E Ehret Georg B GB Zhang Weihua W Lamparter David D Esko Tõnu T Macé Aurelien A Rüeger Sina S Bochud Pierre-Yves PY Barcella Matteo M Dauvilliers Yves Y Benyamin Beben B Evans David M DM Hayward Caroline C Lopez Mary F MF Franke Lude L Russo Alessia A Heid Iris M IM Salvi Erika E Vendantam Sailaja S Arking Dan E DE Boerwinkle Eric E Chambers John C JC Fiorito Giovanni G Grallert Harald H Guarrera Simonetta S Homuth Georg G Huffman Jennifer E JE Porteous David D Moradpour Darius D Iranzo Alex A Hebebrand Johannes J Kemp John P JP Lammers Gert J GJ Aubert Vincent V Heim Markus H MH Martin Nicholas G NG Montgomery Grant W GW Peraita-Adrados Rosa R Santamaria Joan J Negro Francesco F Schmidt Carsten O CO Scott Robert A RA Spector Tim D TD Strauch Konstantin K Völzke Henry H Wareham Nicholas J NJ Yuan Wei W Bell Jordana T JT Chakravarti Aravinda A Kooner Jaspal S JS Peters Annette A Matullo Giuseppe G Wallaschofski Henri H Whitfield John B JB Paccaud Fred F Vollenweider Peter P Bergmann Sven S Beckmann Jacques S JS Tafti Mehdi M Hastie Nicholas D ND Cusi Daniele D Bochud Murielle M Frayling Timothy M TM Metspalu Andres A Jarvelin Marjo-Riitta MR Scherag André A Smith George Davey GD Borecki Ingrid B IB Rousson Valentin V Hirschhorn Joel N JN Rivolta Carlo C Loos Ruth J F RJ Kutalik Zoltán Z
PLoS genetics 20140731 7
The phenotypic effect of some single nucleotide polymorphisms (SNPs) depends on their parental origin. We present a novel approach to detect parent-of-origin effects (POEs) in genome-wide genotype data of unrelated individuals. The method exploits increased phenotypic variance in the heterozygous genotype group relative to the homozygous groups. We applied the method to >56,000 unrelated individuals to search for POEs influencing body mass index (BMI). Six lead SNPs were carried forward for repl ...[more]
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