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Meta-analysis identifies common variants associated with body mass index in east Asians.


ABSTRACT: Multiple genetic loci associated with obesity or body mass index (BMI) have been identified through genome-wide association studies conducted predominantly in populations of European ancestry. We performed a meta-analysis of associations between BMI and approximately 2.4 million SNPs in 27,715 east Asians, which was followed by in silico and de novo replication studies in 37,691 and 17,642 additional east Asians, respectively. We identified ten BMI-associated loci at genome-wide significance (P < 5.0 × 10(-8)), including seven previously identified loci (FTO, SEC16B, MC4R, GIPR-QPCTL, ADCY3-DNAJC27, BDNF and MAP2K5) and three novel loci in or near the CDKAL1, PCSK1 and GP2 genes. Three additional loci nearly reached the genome-wide significance threshold, including two previously identified loci in the GNPDA2 and TFAP2B genes and a newly identified signal near PAX6, all of which were associated with BMI with P < 5.0 × 10(-7). Findings from this study may shed light on new pathways involved in obesity and demonstrate the value of conducting genetic studies in non-European populations.

SUBMITTER: Wen W 

PROVIDER: S-EPMC3288728 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature

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Meta-analysis identifies common variants associated with body mass index in east Asians.

Wen Wanqing W   Cho Yoon-Shin YS   Zheng Wei W   Dorajoo Rajkumar R   Kato Norihiro N   Qi Lu L   Chen Chien-Hsiun CH   Delahanty Ryan J RJ   Okada Yukinori Y   Tabara Yasuharu Y   Gu Dongfeng D   Zhu Dingliang D   Haiman Christopher A CA   Mo Zengnan Z   Gao Yu-Tang YT   Saw Seang-Mei SM   Go Min-Jin MJ   Takeuchi Fumihiko F   Chang Li-Ching LC   Kokubo Yoshihiro Y   Liang Jun J   Hao Mei M   Le Marchand Loïc L   Zhang Yi Y   Hu Yanling Y   Wong Tien-Yin TY   Long Jirong J   Han Bok-Ghee BG   Kubo Michiaki M   Yamamoto Ken K   Su Mei-Hsin MH   Miki Tetsuro T   Henderson Brian E BE   Song Huaidong H   Tan Aihua A   He Jiang J   Ng Daniel P-K DP   Cai Qiuyin Q   Tsunoda Tatsuhiko T   Tsai Fuu-Jen FJ   Iwai Naoharu N   Chen Gary K GK   Shi Jiajun J   Xu Jianfeng J   Sim Xueling X   Xiang Yong-Bing YB   Maeda Shiro S   Ong Rick T H RT   Li Chun C   Nakamura Yusuke Y   Aung Tin T   Kamatani Naoyuki N   Liu Jian-Jun JJ   Lu Wei W   Yokota Mitsuhiro M   Seielstad Mark M   Fann Cathy S J CS   Wu Jer-Yuarn JY   Lee Jong-Young JY   Hu Frank B FB   Tanaka Toshihiro T   Tai E Shyong ES   Shu Xiao-Ou XO  

Nature genetics 20120219 3


Multiple genetic loci associated with obesity or body mass index (BMI) have been identified through genome-wide association studies conducted predominantly in populations of European ancestry. We performed a meta-analysis of associations between BMI and approximately 2.4 million SNPs in 27,715 east Asians, which was followed by in silico and de novo replication studies in 37,691 and 17,642 additional east Asians, respectively. We identified ten BMI-associated loci at genome-wide significance (P  ...[more]

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