Ontology highlight
ABSTRACT:
SUBMITTER: Chen Y
PROVIDER: S-EPMC4117781 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Chen Yujie Y Tokuda Joshua M JM Topping Traci T Sutton Julie L JL Meisburger Steve P SP Pabit Suzette A SA Gloss Lisa M LM Pollack Lois L
Nucleic acids research 20140702 13
The modulation of DNA accessibility by nucleosomes is a fundamental mechanism of gene regulation in eukaryotes. The nucleosome core particle (NCP) consists of 147 bp of DNA wrapped around a symmetric octamer of histone proteins. The dynamics of DNA packaging and unpackaging from the NCP affect all DNA-based chemistries, but depend on many factors, including DNA positioning sequence, histone variants and modifications. Although the structure of the intact NCP has been studied by crystallography a ...[more]