Bending Unwinds DNA.
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ABSTRACT:
SUBMITTER: Chandrasekhar S
PROVIDER: S-EPMC10888926 | biostudies-literature | 2024 Feb
REPOSITORIES: biostudies-literature
Publications
Bending DNA increases its helical repeat.
Chandrasekhar Soumya S Swope Thomas P TP Fadaei Fatemeh F Hollis Daniel R DR Bricker Rachel R Houser Draven D Portman John J JJ Schmidt Thorsten L TL
bioRxiv : the preprint server for biology 20241127
In all biological systems, DNA is under high mechanical stress from bending and twisting. For example, DNA is tightly bent in nucleosome complexes, virus capsids, bacterial chromosomes, or complexes with transcription factors that regulate gene expression. A structurally and mechanically accurate model of DNA is therefore necessary to understand some of the most fundamental molecular mechanisms in biology including DNA packaging, replication, transcription and gene regulation. An iconic feature ...[more]
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