Ontology highlight
ABSTRACT:
SUBMITTER: Ishino S
PROVIDER: S-EPMC4118122 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Ishino Sonoko S Yamagami Takeshi T Kitamura Makoto M Kodera Noriyuki N Mori Tetsuya T Sugiyama Shyogo S Ando Toshio T Goda Natsuko N Tenno Takeshi T Hiroaki Hidekazu H Ishino Yoshizumi Y
The Journal of biological chemistry 20140619 31
Hef is an archaeal protein that probably functions mainly in stalled replication fork repair. The presence of an unstructured region was predicted between the two distinct domains of the Hef protein. We analyzed the interdomain region of Thermococcus kodakarensis Hef and demonstrated its disordered structure by CD, NMR, and high speed atomic force microscopy (AFM). To investigate the functions of this intrinsically disordered region (IDR), we screened for proteins interacting with the IDR of Hef ...[more]