Ontology highlight
ABSTRACT:
SUBMITTER: Luo EC
PROVIDER: S-EPMC4118187 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Scientific reports 20140801
Hypoxia and reoxygenation are common characteristics of solid tumors, which lead to oxidative stress and activation of stress-response genes. Previously, we observed that N-myc downstream-regulated gene 1 (NDRG1) was strongly down-regulated after shifting to reoxygenation, but the regulatory mechanism of NDRG1 remained elusive. Here we focused on the regulation of NDRG1 by microRNAs (miRNAs). Breast cancer MCF-7 cells were cultured under hypoxia for 24 h followed by 24 h of reoxygenation. The mi ...[more]