Ontology highlight
ABSTRACT:
SUBMITTER: Forouhar F
PROVIDER: S-EPMC4118475 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
Forouhar Farhad F Arragain Simon S Atta Mohamed M Gambarelli Serge S Mouesca Jean-Marie JM Hussain Munif M Xiao Rong R Kieffer-Jaquinod Sylvie S Seetharaman Jayaraman J Acton Thomas B TB Montelione Gaetano T GT Mulliez Etienne E Hunt John F JF Fontecave Marc M
Nature chemical biology 20130331 5
How living organisms create carbon-sulfur bonds during the biosynthesis of critical sulfur-containing compounds is still poorly understood. The methylthiotransferases MiaB and RimO catalyze sulfur insertion into tRNAs and ribosomal protein S12, respectively. Both belong to a subgroup of radical-S-adenosylmethionine (radical-SAM) enzymes that bear two [4Fe-4S] clusters. One cluster binds S-adenosylmethionine and generates an Ado• radical via a well-established mechanism. However, the precise role ...[more]