Ontology highlight
ABSTRACT:
SUBMITTER: Doi K
PROVIDER: S-EPMC4119075 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Doi Kenichiro K Liu Qiang Q Gowda Krishne K Barth Brian M BM Claxton David D Amin Shantu S Loughran Thomas P TP Wang Hong-Gang HG
Cancer biology & therapy 20140519 8
Acute myeloid leukemia (AML) is one of the deadliest leukemias for which there is an urgent and unmet need for the development of novel treatment strategies. Multiple drug resistance mechanisms mediate poor drug response and relapse in patients, and a selective Mcl-1 inhibitor has been speculated to be a promising agent in the treatment of AML. Here, we describe that maritoclax, a small molecule Mcl-1 inhibitor, induces Mcl-1 proteasomal degradation without transcriptional downregulation. Marito ...[more]