Ontology highlight
ABSTRACT:
SUBMITTER: Pena-Martinez P
PROVIDER: S-EPMC5843897 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Peña-Martínez P P Eriksson M M Ramakrishnan R R Chapellier M M Högberg C C Orsmark-Pietras C C Richter J J Andersson A A Fioretos T T Järås M M
Leukemia 20170818 3
Cytokines provide signals that regulate immature normal and acute myeloid leukemia (AML) cells in the bone marrow microenvironment. We here identify interleukin 4 (IL4) as a selective inhibitor of AML cell growth and survival in a cytokine screen using fluorescently labeled AML cells. RNA-sequencing of the AML cells revealed an IL4-induced upregulation of Stat6 target genes and enrichment of apoptosis-related gene expression signatures. Consistent with these findings, we found that IL4 stimulati ...[more]