Ontology highlight
ABSTRACT:
SUBMITTER: Uphoff S
PROVIDER: S-EPMC4119245 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Uphoff Stephan S Kapanidis Achillefs N AN
DNA repair 20140312
DNA repair safeguards the genome against a diversity of DNA damaging agents. Although the mechanisms of many repair proteins have been examined separately in vitro, far less is known about the coordinated function of the whole repair machinery in vivo. Furthermore, single-cell studies indicate that DNA damage responses generate substantial variation in repair activities across cells. This review focuses on fluorescence imaging methods that offer a quantitative description of DNA repair in single ...[more]