Ontology highlight
ABSTRACT:
SUBMITTER: Morales M
PROVIDER: S-EPMC4119352 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Morales Mònica M Arenas Enrique J EJ Urosevic Jelena J Guiu Marc M Fernández Esther E Planet Evarist E Fenwick Robert Bryn RB Fernández-Ruiz Sonia S Salvatella Xavier X Reverter David D Carracedo Arkaitz A Massagué Joan J Gomis Roger R RR
EMBO molecular medicine 20140701 7
In estrogen receptor-negative breast cancer patients, metastatic relapse usually occurs in the lung and is responsible for the fatal outcome of the disease. Thus, a better understanding of the biology of metastasis is needed. In particular, biomarkers to identify patients that are at risk of lung metastasis could open the avenue for new therapeutic opportunities. Here we characterize the biological activity of RARRES3, a new metastasis suppressor gene whose reduced expression in the primary brea ...[more]