Ontology highlight
ABSTRACT:
SUBMITTER: Song R
PROVIDER: S-EPMC4119886 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Song Rui R Walentek Peter P Sponer Nicole N Klimke Alexander A Lee Joon Sub JS Dixon Gary G Harland Richard R Wan Ying Y Lishko Polina P Lize Muriel M Kessel Michael M He Lin L
Nature 20140601 7503
The mir-34/449 family consists of six homologous miRNAs at three genomic loci. Redundancy of miR-34/449 miRNAs and their dominant expression in multiciliated epithelia suggest a functional significance in ciliogenesis. Here we report that mice deficient for all miR-34/449 miRNAs exhibited postnatal mortality, infertility and strong respiratory dysfunction caused by defective mucociliary clearance. In both mouse and Xenopus, miR-34/449-deficient multiciliated cells (MCCs) exhibited a significant ...[more]