Ontology highlight
ABSTRACT:
SUBMITTER: Spatazza J
PROVIDER: S-EPMC4119931 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Spatazza Julien J Lee Henry H C HH Di Nardo Ariel A AA Tibaldi Lorenzo L Joliot Alain A Hensch Takao K TK Prochiantz Alain A
Cell reports 20130613 6
Brain plasticity is often restricted to critical periods in early life. Here, we show that a key regulator of this process in the visual cortex, Otx2 homeoprotein, is synthesized and secreted globally from the choroid plexus. Consequently, Otx2 is maintained in selected GABA cells unexpectedly throughout the mature forebrain. Genetic disruption of choroid-expressed Otx2 impacts these distant circuits and in the primary visual cortex reopens binocular plasticity to restore vision in amblyopic mic ...[more]