Ontology highlight
ABSTRACT:
SUBMITTER: Cha J
PROVIDER: S-EPMC4120233 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Cell reports 20140717 2
Embryo homing and implantation occur within a crypt (implantation chamber) at the antimesometrial (AM) pole along the uterus. The mechanism by which this is achieved is not known. Here, we show that villi-like epithelial projections from the main uterine lumen toward the AM pole at regularly spaced intervals that form crypts for embryo implantation were disrupted in mice with uterine loss or gain of function of Wnt5a, or loss of function of both Ror1 and Ror2. This disruption of Wnt5a-ROR signal ...[more]