Ontology highlight
ABSTRACT:
SUBMITTER: Wang ZJ
PROVIDER: S-EPMC4120663 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Angewandte Chemie (International ed. in English) 20140506 26
Engineering enzymes capable of modes of activation unprecedented in nature will increase the range of industrially important molecules that can be synthesized through biocatalysis. However, low activity for a new function is often a limitation in adopting enzymes for preparative-scale synthesis, reaction with demanding substrates, or when a natural substrate is also present. By mutating the proximal ligand and other key active-site residues of the cytochrome P450 enzyme from Bacillus megaterium ...[more]