Ontology highlight
ABSTRACT:
SUBMITTER: Lynes J
PROVIDER: S-EPMC4121445 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Lynes John J Wibowo Mia M Koschmann Carl C Baker Gregory J GJ Saxena Vandana V Muhammad A K M G AK Bondale Niyati N Klein Julia J Assi Hikmat H Lieberman Andrew P AP Castro Maria G MG Lowenstein Pedro R PR
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 20140701 3
In human gliomas, the RTK/RAS/PI(3)K signaling pathway is nearly always altered. We present a model of experimental gliomagenesis that elucidates the contributions of genes involved in this pathway (PDGF-B ligand, HRAS-G12V, and AKT). We also examine the effect on gliomagenesis by the potential modifier gene, IDH1-R132H. Injections of lentiviral-encoded oncogenes induce de novo gliomas of varying penetrance, tumor progression, and histological grade depending on the specific oncogenes used. Our ...[more]