Screening for noise in gene expression identifies drug synergies.
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ABSTRACT:
SUBMITTER: Dar RD
PROVIDER: S-EPMC4122234 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Publications
Screening for noise in gene expression identifies drug synergies.
Dar Roy D RD Hosmane Nina N NN Arkin Michelle R MR Siliciano Robert F RF Weinberger Leor S LS
Science (New York, N.Y.) 20140605 6190
Stochastic fluctuations are inherent to gene expression and can drive cell-fate specification. We used such fluctuations to modulate reactivation of HIV from latency-a quiescent state that is a major barrier to an HIV cure. By screening a diverse library of bioactive small molecules, we identified more than 80 compounds that modulated HIV gene-expression fluctuations (i.e., "noise"), without changing mean expression. These noise-modulating compounds would be neglected in conventional screens, an ...[more]
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