Ontology highlight
ABSTRACT:
SUBMITTER: Moen SO
PROVIDER: S-EPMC4123200 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Moen Spencer O SO Abendroth Jan J Fairman James W JW Baydo Ruth O RO Bullen Jameson J Kirkwood Jennifer L JL Barnes Steve R SR Raymond Amy C AC Begley Darren W DW Henkel Greg G McCormack Ken K Tam Vincent C VC Phan Isabelle I Staker Bart L BL Stacy Robin R Myler Peter J PJ Lorimer Don D Edwards Thomas E TE
Scientific reports 20140804
Influenza A viruses cause the respiratory illness influenza, which can be mild to fatal depending on the strain and host immune response. The flu polymerase acidic (PA), polymerase basic 1 (PB1), and polymerase basic 2 (PB2) proteins comprise the RNA-dependent RNA polymerase complex responsible for viral genome replication. The first crystal structures of the C-terminal domain of PA (PA-CTD) in the absence of PB1-derived peptides show a number of structural changes relative to the previously rep ...[more]