Ontology highlight
ABSTRACT:
SUBMITTER: Lech PJ
PROVIDER: S-EPMC4123749 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Virology 20140314
The measles virus (MV) vaccine lineage is a promising oncolytic but prior exposure to the measles vaccine or wild-type MV strains limits treatment utility due to the presence of anti-measles antibodies. MV entry can be redirected by displaying a polypeptide ligand on the Hemagglutinin (H) C-terminus. We hypothesized that retargeted MV would escape neutralization by monoclonal antibodies (mAbs) recognizing the H receptor-binding surface and be less susceptible to neutralization by human antisera. ...[more]