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Interferons and interferon regulatory factors in malaria.

ABSTRACT: Malaria is one of the most serious infectious diseases in humans and responsible for approximately 500 million clinical cases and 500 thousand deaths annually. Acquired adaptive immune responses control parasite replication and infection-induced pathologies. Most infections are clinically silent which reflects on the ability of adaptive immune mechanisms to prevent the disease. However, a minority of these can become severe and life-threatening, manifesting a range of overlapping syndromes of complex origins which could be induced by uncontrolled immune responses. Major players of the innate and adaptive responses are interferons. Here, we review their roles and the signaling pathways involved in their production and protection against infection and induced immunopathologies.

SUBMITTER: Gun SY

PROVIDER: S-EPMC4124246 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature

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Interferons and interferon regulatory factors in malaria.

Gun Sin Yee SY Gun Sin Yee SY Claser Carla C Tan Kevin Shyong Wei KS Rénia Laurent L

Mediators of inflammation 20140715

Malaria is one of the most serious infectious diseases in humans and responsible for approximately 500 million clinical cases and 500 thousand deaths annually. Acquired adaptive immune responses control parasite replication and infection-induced pathologies. Most infections are clinically silent which reflects on the ability of adaptive immune mechanisms to prevent the disease. However, a minority of these can become severe and life-threatening, manifesting a range of overlapping syndromes of co ...[more]

PMID: 25157202

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