Ontology highlight
ABSTRACT:
SUBMITTER: Jensen MA
PROVIDER: S-EPMC4306637 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Jensen Mark A MA Niewold Timothy B TB
Translational research : the journal of laboratory and clinical medicine 20141013 2
The pathogenesis of systemic lupus erythematosus (SLE) is multifactorial, and the interferon regulatory factors (IRFs) play an important role. Autoantibodies formed in SLE target nuclear antigens, and immune complexes formed by these antibodies contain nucleic acid. These immune complexes can activate antiviral pattern recognition receptors (PRRs), resulting in the downstream activation of IRFs, which can induce type I interferon (IFN-I) and other inflammatory mediators. Genetic variations in IR ...[more]