Ontology highlight
ABSTRACT:
SUBMITTER: Maeda A
PROVIDER: S-EPMC4124513 | biostudies-literature | 2006 Dec
REPOSITORIES: biostudies-literature
Maeda Akiko A Maeda Tadao T Imanishi Yoshikazu Y Sun Wenyu W Jastrzebska Beata B Hatala Denise A DA Winkens Huub J HJ Hofmann Klaus Peter KP Janssen Jacques J JJ Baehr Wolfgang W Driessen Carola A CA Palczewski Krzysztof K
The Journal of biological chemistry 20061010 49
RDH12 has been suggested to be one of the retinol dehydrogenases (RDH) involved in the vitamin A recycling system (visual cycle) in the eye. Loss of function mutations in the RDH12 gene were recently reported to be associated with autosomal recessive childhood-onset severe retinal dystrophy. Here we show that RDH12 localizes to the photoreceptor inner segments and that deletion of this gene in mice slows the kinetics of all-trans-retinal reduction, delaying dark adaptation. However, accelerated ...[more]