Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization.
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ABSTRACT:
SUBMITTER: Arking DE
PROVIDER: S-EPMC4124521 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Publications
Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization.
Arking Dan E DE Pulit Sara L SL Crotti Lia L van der Harst Pim P Munroe Patricia B PB Koopmann Tamara T TT Sotoodehnia Nona N Rossin Elizabeth J EJ Morley Michael M Wang Xinchen X Johnson Andrew D AD Lundby Alicia A Gudbjartsson Daníel F DF Noseworthy Peter A PA Eijgelsheim Mark M Bradford Yuki Y Tarasov Kirill V KV Dörr Marcus M Müller-Nurasyid Martina M Lahtinen Annukka M AM Nolte Ilja M IM Smith Albert Vernon AV Bis Joshua C JC Isaacs Aaron A Newhouse Stephen J SJ Evans Daniel S DS Post Wendy S WS Waggott Daryl D Lyytikäinen Leo-Pekka LP Hicks Andrew A AA Eisele Lewin L Ellinghaus David D Hayward Caroline C Navarro Pau P Ulivi Sheila S Tanaka Toshiko T Tester David J DJ Chatel Stéphanie S Gustafsson Stefan S Kumari Meena M Morris Richard W RW Naluai Åsa T ÅT Padmanabhan Sandosh S Kluttig Alexander A Strohmer Bernhard B Panayiotou Andrie G AG Torres Maria M Knoflach Michael M Hubacek Jaroslav A JA Slowikowski Kamil K Raychaudhuri Soumya S Kumar Runjun D RD Harris Tamara B TB Launer Lenore J LJ Shuldiner Alan R AR Alonso Alvaro A Bader Joel S JS Ehret Georg G Huang Hailiang H Kao W H Linda WH Strait James B JB Macfarlane Peter W PW Brown Morris M Caulfield Mark J MJ Samani Nilesh J NJ Kronenberg Florian F Willeit Johann J Smith J Gustav JG Greiser Karin H KH Meyer Zu Schwabedissen Henriette H Werdan Karl K Carella Massimo M Zelante Leopoldo L Heckbert Susan R SR Psaty Bruce M BM Rotter Jerome I JI Kolcic Ivana I Polašek Ozren O Wright Alan F AF Griffin Maura M Daly Mark J MJ Arnar David O DO Hólm Hilma H Thorsteinsdottir Unnur U Denny Joshua C JC Roden Dan M DM Zuvich Rebecca L RL Emilsson Valur V Plump Andrew S AS Larson Martin G MG O'Donnell Christopher J CJ Yin Xiaoyan X Bobbo Marco M D'Adamo Adamo P AP Iorio Annamaria A Sinagra Gianfranco G Carracedo Angel A Cummings Steven R SR Nalls Michael A MA Jula Antti A Kontula Kimmo K KK Marjamaa Annukka A Oikarinen Lasse L Perola Markus M Porthan Kimmo K Erbel Raimund R Hoffmann Per P Jöckel Karl-Heinz KH Kälsch Hagen H Nöthen Markus M MM den Hoed Marcel M Loos Ruth J F RJ Thelle Dag S DS Gieger Christian C Meitinger Thomas T Perz Siegfried S Peters Annette A Prucha Hanna H Sinner Moritz F MF Waldenberger Melanie M de Boer Rudolf A RA Franke Lude L van der Vleuten Pieter A PA Beckmann Britt Maria BM Martens Eimo E Bardai Abdennasser A Hofman Nynke N Wilde Arthur A M AA Behr Elijah R ER Dalageorgou Chrysoula C Giudicessi John R JR Medeiros-Domingo Argelia A Barc Julien J Kyndt Florence F Probst Vincent V Ghidoni Alice A Insolia Roberto R Hamilton Robert M RM Scherer Stephen W SW Brandimarto Jeffrey J Margulies Kenneth K Moravec Christine E CE del Greco M Fabiola F Fuchsberger Christian C O'Connell Jeffrey R JR Lee Wai K WK Watt Graham C M GC Campbell Harry H Wild Sarah H SH El Mokhtari Nour E NE Frey Norbert N Asselbergs Folkert W FW Mateo Leach Irene I Navis Gerjan G van den Berg Maarten P MP van Veldhuisen Dirk J DJ Kellis Manolis M Krijthe Bouwe P BP Franco Oscar H OH Hofman Albert A Kors Jan A JA Uitterlinden André G AG Witteman Jacqueline C M JC Kedenko Lyudmyla L Lamina Claudia C Oostra Ben A BA Abecasis Gonçalo R GR Lakatta Edward G EG Mulas Antonella A Orrú Marco M Schlessinger David D Uda Manuela M Markus Marcello R P MR Völker Uwe U Snieder Harold H Spector Timothy D TD Ärnlöv Johan J Lind Lars L Sundström Johan J Syvänen Ann-Christine AC Kivimaki Mika M Kähönen Mika M Mononen Nina N Raitakari Olli T OT Viikari Jorma S JS Adamkova Vera V Kiechl Stefan S Brion Maria M Nicolaides Andrew N AN Paulweber Bernhard B Haerting Johannes J Dominiczak Anna F AF Nyberg Fredrik F Whincup Peter H PH Hingorani Aroon D AD Schott Jean-Jacques JJ Bezzina Connie R CR Ingelsson Erik E Ferrucci Luigi L Gasparini Paolo P Wilson James F JF Rudan Igor I Franke Andre A Mühleisen Thomas W TW Pramstaller Peter P PP Lehtimäki Terho J TJ Paterson Andrew D AD Parsa Afshin A Liu Yongmei Y van Duijn Cornelia M CM Siscovick David S DS Gudnason Vilmundur V Jamshidi Yalda Y Salomaa Veikko V Felix Stephan B SB Sanna Serena S Ritchie Marylyn D MD Stricker Bruno H BH Stefansson Kari K Boyer Laurie A LA Cappola Thomas P TP Olsen Jesper V JV Lage Kasper K Schwartz Peter J PJ Kääb Stefan S Chakravarti Aravinda A Ackerman Michael J MJ Pfeufer Arne A de Bakker Paul I W PI Newton-Cheh Christopher C
Nature genetics 20140622 8
The QT interval, an electrocardiographic measure reflecting myocardial repolarization, is a heritable trait. QT prolongation is a risk factor for ventricular arrhythmias and sudden cardiac death (SCD) and could indicate the presence of the potentially lethal mendelian long-QT syndrome (LQTS). Using a genome-wide association and replication study in up to 100,000 individuals, we identified 35 common variant loci associated with QT interval that collectively explain ∼8-10% of QT-interval variation ...[more]
