Ontology highlight
ABSTRACT:
SUBMITTER: Kust N
PROVIDER: S-EPMC4125163 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Kust Nadezda N Rybalkina Ekaterina E Mertsalov Ilya I Savchenko Ekaterina E Revishchin Alexander A Pavlova Gali G
PloS one 20140807 8
The activation of genetic constructs including the Drosophila hsp70 promoter with four and eight HSE sequences in the regulatory region has been described in human cells. The promoter was shown to be induced at lower temperatures compared to the human hsp70 promoter. The promoter activity increased after a 60-min heat shock already at 38 °C in human cells. The promoter activation was observed 24 h after heat shock for the constructs with eight HSEs, while those with four HSEs required 48 h. Afte ...[more]