Ontology highlight
ABSTRACT:
SUBMITTER: French CA
PROVIDER: S-EPMC4125436 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
French Christopher A CA Rahman Shaila S Walsh Erica M EM Kühnle Simone S Grayson Adlai R AR Lemieux Madeleine E ME Grunfeld Noam N Rubin Brian P BP Antonescu Cristina R CR Zhang Songlin S Venkatramani Rajkumar R Dal Cin Paola P Howley Peter M PM
Cancer discovery 20140529 8
<h4>Unlabelled</h4>NUT midline carcinoma (NMC) is an aggressive subtype of squamous cell carcinoma that typically harbors BRD4/3-NUT fusion oncoproteins that block differentiation and maintain tumor growth. In 20% of cases, NUT is fused to uncharacterized non-BRD gene(s). We established a new patient-derived NMC cell line (1221) and demonstrated that it harbors a novel NSD3-NUT fusion oncogene. We find that NSD3-NUT is both necessary and sufficient for the blockade of differentiation and mainten ...[more]