Ontology highlight
ABSTRACT:
SUBMITTER: O'Neal SL
PROVIDER: S-EPMC4126163 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Toxicology letters 20140612 1
Literature data indicate that bone is a major storage organ for manganese (Mn), accounting for 43% of total body Mn. However, the kinetic nature of Mn in bone, especially the half-life (t(1/2)), remained unknown. This study was designed to understand the time-dependence of Mn distribution in rat bone after chronic oral exposure. Adult male rats received 50 mg Mn/kg (as MnCl2) by oral gavage, 5 days per week, for up to 10 weeks. Animals were sacrificed every 2 weeks during Mn administration for t ...[more]