Ontology highlight
ABSTRACT:
SUBMITTER: Wang X
PROVIDER: S-EPMC4127372 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Wang Xiaoming X Paul Jonathan A JA Nanovskaya Tatiana N TN Hankins Gary D V GD Ahmed Mahmoud S MS
Journal of pharmaceutical and biomedical analysis 20140502
The increasing incidence and severity of methicillin- and vancomycin-resistant infections during pregnancy prompted further development of telavancin. The understanding of the pharmacokinetics of telavancin during pregnancy is critical to optimize dosing. Due to ethical and safety concerns the study is conducted on the pregnant baboons. A method using solid-phase extraction coupled with liquid chromatography-single quadrupole mass spectrometry for the quantitative determination of telavancin in ...[more]