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Passive tumor targeting of renal-clearable luminescent gold nanoparticles: long tumor retention and fast normal tissue clearance.

ABSTRACT: Glutathione-coated luminescent gold nanoparticles (GS-AuNPs) with diameters of ?2.5 nm behave like small dye molecules (IRDye 800CW) in physiological stability and renal clearance but exhibit a much longer tumor retention time and faster normal tissue clearance, indicating that the well-known enhanced permeability and retention effect, a unique strength of conventional NPs in tumor targeting, still exists in such small NPs. These merits enable the AuNPs to detect tumor more rapidly than the dye molecules without severe accumulation in reticuloendothelial system organs, making them very promising for cancer diagnosis and therapy.

SUBMITTER: Liu J

PROVIDER: S-EPMC4127425 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature

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Passive tumor targeting of renal-clearable luminescent gold nanoparticles: long tumor retention and fast normal tissue clearance.

Liu Jinbin J Yu Mengxiao M Zhou Chen C Yang Shengyang S Ning Xuhui X Zheng Jie J

Journal of the American Chemical Society 20130322 13

Glutathione-coated luminescent gold nanoparticles (GS-AuNPs) with diameters of ∼2.5 nm behave like small dye molecules (IRDye 800CW) in physiological stability and renal clearance but exhibit a much longer tumor retention time and faster normal tissue clearance, indicating that the well-known enhanced permeability and retention effect, a unique strength of conventional NPs in tumor targeting, still exists in such small NPs. These merits enable the AuNPs to detect tumor more rapidly than the dye ...[more]

PMID: 23506476

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