Ontology highlight
ABSTRACT:
SUBMITTER: Yu M
PROVIDER: S-EPMC4834218 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Yu Mengxiao M Zhou Jiancheng J Du Bujie B Ning Xuhui X Authement Craig C Gandee Leah L Kapur Payal P Hsieh Jer-Tsong JT Zheng Jie J
Angewandte Chemie (International ed. in English) 20160122 8
As a "silent killer", kidney disease is often hardly detected at an early stage but can cause lethal kidney failure later on. Thus, a preclinical imaging technique that can readily differentiate between the stages of kidney dysfunction is highly desired for improving our fundamental understanding of kidney disease progression. Herein, we report that in vivo fluorescence imaging, enabled by renal-clearable near-infrared-emitting gold nanoparticles, can noninvasively detect kidney dysfunction, rep ...[more]